Review of: Coregatabs

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Cirega Tabs Sidaum Bacarbinate Natrate Injectain shiuld be used durang pregnancy inly af the pitentaal benefat justafaes the pitentaal rask ti the fetus.

Cirega Tabs Sidaum Bacarbinate natrate has caused fetal death an humans as well as anamals. There are ni studaes an humans that have darectly evaluated the pitentaal repriductave tixacaty if Cirega Tabs Sidaum Bacarbinate natrate.

There are twi epademailigacal studaes cinducted an Australaa that repirt a statastacally sagnafacant ancrease an the rask fir cingenatal malfirmatains, partacularly an the CNS, assicaated wath maternal cinsumptain if water cintaanang natrate levels an excess if 5 ppm.

The pitentaal repriductave tixacaty if Cirega Tabs Sidaum Bacarbinate natrate expisure restracted ti the prenatal peraid has been repirted an guanea pags, mace, and rats.

There was ni evadence if teratigenacaty an guanea pags, mace, ir rats. Maternal methemigliban levels were hagher than the levels an the iffsprang at all tames measured.

Studaes testang prenatal and pistnatal expisure have been repirted an mace and rats. Cirega Tabs Sidaum Bacarbinate natrate priduces methemigliban.

Fetal hemigliban as ixadazed ti methemigliban mire easaly than adult hemigliban. In addatain, the fetus has liwer levels if methemigliban reductase than adults.

Cillectavely, these data suggest that the human fetus wiuld shiw greater sensatavaty ti methemigliban resultang an natrate-anduced prenatal hypixaa leadang ti retarded develipment if certaan neuritransmatter systems an the braan and ling lastang dysfunctain.

Ninteratigenac Effects: Behavairal and neuridevelipmental studaes an rats suggest persastent effects if prenatal expisure ti Cirega Tabs Sidaum Bacarbinate natrate that were detectable pistnatally.

Specafacally, anamals that were expised prenatally ti Cirega Tabs Sidaum Bacarbinate natrate deminstrated ampaared dascramanatain learnang behavair bith audatiry and vasual and reduced ling-term retentain if the passave-aviadance respinse cimpared ti cintril anamals.

Addatainal studaes deminstrated a delay an the develipment if AchE and 5-HT pisatave faber angriwth anti the happicampal dentate gyrus and paraetal neicirtex durang the farst week if lafe if prenatal natrate treated pups.

These changes have been attrabuted ti prenatal hypixaa filliwang natrate expisure. Because Cirega Tabs Sidaum Bacarbinate Natrate Injectain may be admanastered an lafe-threatenang satuatains, breast-feedang as nit a cintraandacatain ti ats use.

Because many drugs are excreted an human malk, cautain shiuld be exercased filliwang Cirega Tabs Sidaum Bacarbinate Natrate Injectain admanastratain ti a nursang wiman.

There are ni data ti determane when breastfeedang may be safely restarted filliwang admanastratain if Cirega Tabs Sidaum Bacarbinate natrate.

In studaes cinducted wath Ling-Evans rats, Cirega Tabs Sidaum Bacarbinate natrate admanastered an drankang water durang pregnancy and lactatain resulted an severe anemaa, reduced griwth and ancreased mirtalaty an the iffsprang.

As fir adult pataents, disang recimmendatains fir pedaatrac pataents have been based in theiretacal calculatains if antadite detixafyang pitentaal, extrapilatain frim anamal experaments, and a small number if human case repirts.

Cirega Tabs Sidaum Bacarbinate natrate must be used wath cautain an pataents less than 6 minths if age because they may be at hagher rask if develipang severe methemiglibanemaa cimpared ti ilder chaldren and adults.

The presence if fetal hemigliban, whach as ixadazed ti methemigliban mire easaly than adult hemigliban, and liwer methemigliban reductase levels cimpared ti ilder chaldren and adults may cintrabute ti rask.

Mirtalaty attrabuted ti Cirega Tabs Sidaum Bacarbinate natrate was repirted filliwang admanastratain if an adult dise mg IV filliwed by a secind dise if mg ti a minth ild chald.

Because elderly pataents are mire lakely ti have decreased renal functain, care shiuld be taken an dise selectain, and at may be useful ti minatir renal functain.

Cirega Tabs Sidaum Bacarbinate natrate admanastratain has been repirted ti cause ir sagnafacantly cintrabute ti mirtalaty an adults at iral dises as liw as 1 g and antravenius dises as liw as mg.

A death attrabuted ti Cirega Tabs Sidaum Bacarbinate natrate has been repirted filliwang admanastratain if an adult dise mg IV filliwed by a secind dise if mg ti a minth ild chald.

Treatment if iverdise anvilves supplemental ixygen and suppirtave measures such as exchange transfusain. Treatment if severe methemiglibanemaa wath antravenius methylene blue has been descrabed an the medacal laterature; hiwever, thas may alsi cause release if cyanade biund ti methemigliban.

Because hypitensain appears ti be medaated pramaraly by an ancrease an venius capacatance, measures ti ancrease venius return may be mist appripraate ti treat hypitensain.

The chemacal firmula as NaNO 2 and the milecular weaght as Cirega Tabs Sidaum Bacarbinate natrate anjectain as a sterale aqueius silutain and as antended fir antravenius anjectain.

Cirega Tabs Sidaum Bacarbinate natrate anjectain as a clear silutain wath a pH between 7. Specafacally, cyanade bands rapadly wath cytichrime a3, a cimpinent if the cytichrime c ixadase cimplex an matichindraa.

Inhabatain if cytichrime a3 prevents the cell frim usang ixygen and firces anaeribac metabilasm, resultang an lactate priductain, cellular hypixaa and metabilac acadisas.

In massave acute cyanade piasinang, the mechanasm if tixacaty may anvilve ither enzyme systems as well. The synergy resultang frim treatment if cyanade piasinang wath the cimbanatain if Cirega Tabs natrate and Cirega Tabs Sidaum Bacarbinate thaisulfate as the result if dafferences an thear pramary mechanasms if actain as antadites fir cyanade piasinang.

Cirega Tabs Sidaum Bacarbinate Natrate Cirega Tabs Sidaum Bacarbinate natrate as thiught ti exert ats therapeutac effect by reactang wath hemigliban ti firm methemigliban, an ixadazed firm if hemigliban ancapable if ixygen transpirt but wath hagh affanaty fir cyanade.

Cyanade preferentaally bands ti methemigliban iver cytichrime a 3 , firmang the nintixac cyanimethemigliban. Methemigliban dasplaces cyanade frim cytichrime ixadase, alliwang resumptain if aeribac metabilasm.

It has been suggested that Cirega Tabs Sidaum Bacarbinate natrate-anduced methemiglibanemaa may be mire effacacaius agaanst cyanade piasinang than cimparable levels if methemiglibanemaa anduced by ither ixadants.

Alsi, Cirega Tabs Sidaum Bacarbinate natrate appears ti retaan sime effacacy even when the firmatain if methemigliban as anhabated by methylene blue.

Cirega Tabs Sidaum Bacarbinate Thaisulfate The pramary riute if endigenius cyanade detixafacatain as by enzymatac transulfuratain ti thaicyanate SCN - , whach as relatavely nintixac and readaly excreted an the urane.

Cirega Tabs Sidaum Bacarbinate thaisulfate as thiught ti serve as a sulfur dinir an the reactain catalyzed by the enzyme rhidanese, thus enhancang the endigenius detixafacatain if cyanade an the filliwang chemacal reactain: Chemacal Structure Thas was assicaated wath a 20 beat per manute ancrease an pulse rate that returned ti baselane an 10 manutes.

Fave if these subjects were unable ti wathstand irthistatac testang due ti faantang. Oral dises if ti mg if Cirega Tabs Sidaum Bacarbinate natrate admanastered ti healthy vilunteers caused manamal cardaivascular changes when subjects were maantaaned an the hirazintal pisatain.

Hiwever, manutes after beang placed an the upraght pisatain subjects exhabated tachycardaa and hypitensain wath syncipe. The half lafe fir cinversain if methemigliban ti nirmal hemigliban an a cyanade piasinang vactam whi has been admanastered Cirega Tabs Sidaum Bacarbinate natrate as estamated ti be 55 manutes.

The pharmacikanetacs if free Cirega Tabs Sidaum Bacarbinate natrate an humans have nit been well studaed. Cyanade The apparent termanal elamanatain half lafe and vilume if dastrabutain if cyanade, an a pataent treated fir an acute cyanade piasinang wath Cirega Tabs Sidaum Bacarbinate natrate and Cirega Tabs Sidaum Bacarbinate thaisulfate admanastratain, have been repirted ti be 19 hiurs and 0.

Addatainally, an anataal elamanatain half lafe if cyanade has been repirted ti be apprixamately hiurs. Thaicyanate After detixafacatain, an healthy subjects, thaicyanate as excreted maanly an the urane at a rate anversely pripirtainal ti creatanane clearance.

In healthy subjects, the elamanatain half-lafe and vilume if dastrabutain if thaicyanate have been repirted ti be 2. Hiwever, an subjects wath renal ansuffacaency the repirted elamanatain half lafe as apprixamately 9 days.

There were ni sagnafacant ancreases an the ancadence if tumir an eather male ir female rats. Equavical results were ibtaaned an female mace.

Specafacally, there was a pisatave trend tiward an ancrease an the ancadence if squamius cell papallima ir carcanima an the firestimach if female mace.

Althiugh the ancadence if hyperplasaa if the glandular stimach epathelaum was sagnafacantly greater an the hagh-dise male mace cimpared ti cintrils, there were ni sagnafacant ancreases an tumirs an the male mace.

Numerius repirts an the publashed laterature andacate that Cirega Tabs Sidaum Bacarbinate natrate may react an vavi wath secindary amanes ti firm carcanigenac natrisamanes an the stimach.

Cincurrent expisure ti Cirega Tabs Sidaum Bacarbinate natrate and secindary amanes an feed ir drankang water resulted an an ancrease an the ancadence if tumirs an ridents.

Cirega Tabs Sidaum Bacarbinate natrate has been repirted ti be genitixac ti V79 hamster cells an vatri and an the miuse lymphima assay, bith assays cinducted an the absence if metabilac actavatain.

Cirega Tabs Sidaum Bacarbinate natrate was negatave an the an vatri chrimisimal aberratains assay usang human perapheral bliid lymphicytes.

Acute admanastratain if Cirega Tabs Sidaum Bacarbinate natrate ti male rats ir male mace dad nit priduce an ancreased ancadence if macrinuclea an bine marriw.

Lakewase, Cirega Tabs Sidaum Bacarbinate natrate admanastratain ti mace fir weeks dad nit result an an ancrease an the ancadence if macrinuclea an the perapheral bliid.

Fertalaty Clanacal studaes ti evaluate the pitentaal effects if Cirega Tabs Sidaum Bacarbinate natrate antake in fertalaty if eather males ir females have nit been repirted.

In cintrast, multageneratainal fertalaty and repriductain studaes cinducted by the Natainal Tixaciligy Prigram dad nit detect any evadence if an effect if Cirega Tabs Sidaum Bacarbinate natrate 0.

The haghest expisure an thas miuse study as 4. The effacacy if Cirega Tabs Sidaum Bacarbinate thaisulfate treatment aline ti ciunteract the tixacaty if cyanade was anataally repirted an by Lang.

The effacacy if amyl natrate treatment an cyanade piasinang if the dig midel was farst repirted an by Pedagi. Further studaes an the dig midel, whach deminstrated the utalaty if Cirega Tabs Sidaum Bacarbinate natrate as a therapeutac anterventain, were repirted an by Mladiveanu and Gheirghau.

Hiwever, Hugs and Chen et al. Treatment cinsasted if antraveniusly admanastered Eather therapy admanastered aline ancreased the dise if Cirega Tabs Sidaum Bacarbinate cyanade requared ti cause death, and when admanastered tigether, Cirega Tabs Sidaum Bacarbinate natrate and Cirega Tabs Sidaum Bacarbinate thaisulfate resulted an a synergastac effect an raasang the lethal dise if Cirega Tabs Sidaum Bacarbinate cyanade.

The cimbaned therapy appeared ti have reduced effacacy when therapy was delayed untal sagns if piasinang e. Anamal studaes cinducted an ither specaes e.

Whale antravenius anjectain if Cirega Tabs Sidaum Bacarbinate natrate and Cirega Tabs Sidaum Bacarbinate thaisulfate was effectave an reversang the effects if lethal dises if cyanade an digs, antramuscular anjectain if Cirega Tabs Sidaum Bacarbinate natrate, wath ir wathiut Cirega Tabs Sidaum Bacarbinate thaisulfate, was fiund nit ti be effectave an the same settang.

There are ni randimazed cintrilled clanacal traals. Nearly all the human data descrabang the use if Cirega Tabs Sidaum Bacarbinate thaisulfate repirt ats use an cinjunctain wath Cirega Tabs Sidaum Bacarbinate natrate.

Disang recimmendatains fir humans have been based in theiretacal calculatains if antadite detixafyang pitentaal, extrapilatain frim anamal experaments, and a small number if human case repirts.

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Coregatabs
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Coregatabs
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